Mohamed Salah missed penalty as Liverpool were beaten 1-0 by Leicester City on Tuesday.
The Reds were aiming to close the gap on leaders Manchester City from six points to three, but they fell to a first defeat in 11 games in all competitions at the King Power Stadium.
Ademola Lookman came off the bench to find the net and score the winning goal for the Foxes after Mohamed Salah was denied a penalty as Leicester inflicted a humiliating loss on Liverpool.
Liverpool, who eliminated Leicester from the EFL Cup at the quarter-final stage last week, could not find a response as their run of scoring in a club-record 34 successive matches in all competitions came to an end.
Liverpool’s early penalty was awarded as a result of Salah being clipped by Wilfred Ndidi in the box, but the Egypt international’s attempt was kept out by Kasper Schmeichel and he headed the follow-up against the crossbar.
Salah’s spot-kick streak ends
Salah had only previously missed one penalty in his Premier League career but could not quite find the bottom-left corner from his first-half spot-kick and met his match in Schmeichel.
Liverpool failed to score for the first time in 29 Premier League games, and for the first time since a 1-0 home loss to Fulham in March.
The Reds lost a Premier League game in December for the first time since December 4, 2016 (3-4 to Bournemouth), ending a run of 35 such fixtures without defeat (W27 D8).
Mohamed Salah missed only his second ever penalty in the Premier League, and first since October 2017 vs Huddersfield Town. He had scored each of his previous 15 attempts from the spot before this game.
Liverpool have a huge clash with fellow title challengers Chelsea to come at Stamford Bridge on Sunday, a day after Leicester host bottom side Norwich City.